3D bioprinting technology to be used for removing cancer cells

- KIMM develops the world’s first 3D bioprinting technology that enhances the function of NK immune cells -

 - New technology expected to improve effectiveness of cancer treatment -

□ A three-dimensional (3D) bioprinting technology capable of eliminating cancer cells using the function of immune cells has been developed for the first time in the world.

□ Through joint research with the Korea Institute of Machinery and Materials (President Sang Jin Park, hereinafter referred to as KIMM), the Korea Research Institute of Bioscience and Biotechnology (President Jang Seong Kim, hereinafter referred to as KRIBB), institute under the jurisdiction of the Ministry of Science and ICT, developed a 3D bioprinting technology using natural killer cells (NK cells)* as a new method of immunotherapy for treating cancer, and announced the outcome of the research on  Biomaterials Research (IF: 11. 3)**, a renowned journal.

 * NK cell: Natural killer (NK) cell is a leukocyte that responds to the formation of viruses and tumor cells, and selectively kills cells that are harmful to the human body. NK cells remove distressed cells that have been infected internally, rather than viruses that have intruded from the outside.

** Title: NK cells encapsulated in micro/macropore-forming hydrogels via 3D bioprinting for tumor immunotherapy (date of publication: June 22, 2023)

□ Allowing the 3D-printed hydrogels to encapsulate NK cells helps to prevent the loss of NK cells and enables a majority of those cells to home in on the tumor cells. Pores form in the hydrogel, and NK cells that retain cell viability are released after a certain amount of time, which allows for the performance of immune functions.

□ Although NK cells are generally used for immunotherapy, the method of injecting NK cells via intravenous injection has not shown effective results in clinical trials on solid tumors*. This is because NK cells are incapable of retaining an appropriate level of viability and fail to target solid tumors..

 * Solid tumors: Solid tumors refer to malignant tumors that are composed of vascular and connective tissues and have solidity and form.

□ On the other hand, by using the newly developed technology, NK cells can be injected into the hydrogel, printed, and then cultured in a 3D environment, which enhances the cell viability and activity of NK cells and enables those cells to confront cancer tissues.

□ The newly developed technology helps to enhance machining quality by reducing cross-coupling errors through a more precise position correction by the vision system of the scanner. Additionally, the cutting gas nozzle can be attached separately to the scanner or another stage, improving cutting quality. Furthermore, the vision system corrects the center position for laser beam irradiation at the nozzle throat. This allows high-speed welding and partial cutting at the same time, which helps reducing costs and processing time.

□ Principal Researcher Su A Park of KIMM was quoted as saying, “This technology can help to significantly improve the functionality of NK cells that are used for cancer treatment. We expect to contribute to the treatment of cancer patients through this newly developed technology.”

□ This research was carried out with the support of the project for the “Development of multiscale-vasculature-laden skin composite tissue for evaluation of implantable nano-bio-sensors” sponsored by the Ministry of Science and ICT and the National Research Foundation of Korea, and the project for the “development of UnTACT systems for critical illnesses” conducted by the Convergence Research Center of the National Research Council of Science and Technology.

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The Korea Institute of Machinery and Materials (KIMM) is a non-profit government-funded research institute under the Ministry of Science and ICT. Since its foundation in 1976, KIMM is contributing to economic growth of the nation by performing R&D on key technologies in machinery and materials, conducting reliability test evaluation, and commercializing the developed products and technologies.

This research was carried out with the support of the project for the “Development of multiscale-vasculature-laden skin composite tissue for evaluation of implantable nano-bio-sensors” sponsored by the Ministry of Science and ICT and the National Research Foundation of Korea, and the project for the “development of UnTACT systems for critical illnesses” conducted by the Convergence Research Center of the National Research Council of Science and Technology.